Understanding Platelet‑Rich Fibrin

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Miron, Richard J.
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Understanding Platelet‑Rich Fibrin

Richard J. Miron

Platelet concentrates have been used in medicine for over 20 years now, but the last 5 years have witnessed an explosion in research on platelet-rich fibrin (PRF) because of its ability to promote healing of both bone and soft tissue.
This has led to a marked increase in our understanding of PRF therapy with respect to selection of appropriate centrifugation devices, impact of tube chemistry on clotting, the optimization of protocols to better concentrate PRF, and even the ability to extend the working properties of PRF from 2–3 weeks to 4–6 months using a simple heating process.
Bringing together expert researchers and clinicians from various dental specialties, this book first explores the biology of PRF and then demonstrates its myriad clinical applications in periodontology, implant dentistry, oral and maxillofacial surgery, endodontics, facial esthetics, and medicine.
The true value of this book lies in the blend of data and clinical application, so readers can feel confident knowing that the protocols recommended are fully supported by scientific evidence and demonstrated step by step by clinicians already using them in their daily practice.
Even better, supplementary videos throughout showcase these procedures for better understanding. As Dr Robert E. Marx writes, “Understanding Platelet-Rich Fibrin is a book for this decade that transcends all specialties of dentistry and many of medicine,” so it’s definitely one you’ll want to read.


  1. Evolution of Platelet Concentrates

Section I. Biology of PRF

  1. Biology of PRF: Fibrin Matrix, Growth Factor Release, and Cellular Activity
  2. Horizontal Versus Fixed-Angle Centrifugation of PRF: Optimization of C-PRF
  3. Understanding Relative Centrifugal Force (G-Force)
  4. Importance of Centrifugation Tubes for the Production of PRF
  5. Protocols for PRF
  6. Biologic Characterization of e-PRF Membranes
  7. Armamentarium in a PRF Kit
  8. Phlebotomy
  9. Fabricating Various PRF Modalities
  10. Overview of Clinical Indications Using PRF

Section II. Periodontology

  1. Use of PRF for the Treatment of Gingival Recessions
  2. Use of PRF for the Treatment of Intrabony and Furcation Defects
  3. Use of PRF for Extraction Site Management

Section III. Implant Dentistry

  1. Use of PRF as an Adjunct Therapy to Implant Dentistry
  2. Use of PRF in Guided Bone Regeneration
  3. Use of PRF for Sinus Grafting

Section IV. Additional Dental and Medical Applications

  1. Use of PRF in Oral and Maxillofacial Surgery
  2. Use of PRF in Regenerative Endodontics
  3. Use of PRF in Facial Esthetics
  4. Medical Uses of PRF
  5. Future Research with PRF

Dr. med. dent. Richard J. Miron DDS, BMSc, MSc, PhD:
Vereinigte Staaten von Amerika, Fort Lauderdale, FL
Richard J. Miron, DDS, BMSc, MSc, PhD, Dr med dent, is currently the lead educator and researcher at Advanced PRF Education and is Adjunct Visiting Faculty in the Department of Periodontology at the University of Bern, Switzerland, where he completed his PhD studies. He has published over 250 peer-reviewed articles and lectures internationally on many topics relating to growth factors, bone biomaterials, and guided bone regeneration. Widely considered to be one of the top contributors to research in dentistry, Dr Miron was recognized as the top-ranked researcher on PRF therapy in 2020 according to Expertscape independent review. He also recently won the ITI André Schroeder Prize, the IADR Young Investigator of the Year in the field of implant dentistry, as well as the IADR Socransky Research Award in the field of periodontology. Dr Miron has written five textbooks on regenerative dentistry, and he’s just getting started.